Meloxicam (also known as Mobic) is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and fever reducer results It is a derivative of oxicam, carefully related to piroxicam, and falls in the enolic acid group of NSAIDs. It was developed by Boehringer-Ingelheim. Meloxicam begins to ease pain about 30-60 minutes after administration.
The cost for a common month of medication in the United States is less than $25 USD.
Meloxicam Side Effects
Meloxicam use can result in intestinal toxicity and bleeding, headaches, rash, and very dark or black stool (a sign of digestive bleeding). Like other NSAIDs, its use is related to an increased risk of cardiovascular occasions such as cardiovascular disease and stroke. It has fewer gastrointestinal side effects than diclofenac, piroxicam, naproxen, and perhaps all other NSAIDs which are not COX-2 selective. Although meloxicam prevents development of thromboxane A, it does not appear to do so at levels that would disrupt platelet function.
A pooled analysis of randomized, regulated research studies of meloxicam therapy of approximately 60 days period discovered that meloxicam was associated with a statistically substantially lower variety of thromboembolic complications than the NSAID diclofenac (0.2% versus 0.8% respectively) but a similar incidence of thromboembolic occasions to naproxen and piroxicam.
Cardiovascular Side Effects of Meloxicam
Individuals with hypertension, high cholesterol, or diabetes are at risk for cardiovascular side effects. Individuals with household history of heart disease, cardiovascular disease, or stroke must tell their treating physician as the capacity for severe cardiovascular side effects is substantial.
Mechanism of Action
Meloxicam obstructs cyclooxygenase (COX), the enzyme responsible for transforming arachidonic acid into prostaglandin H2 – the initial step in the synthesis of prostaglandins, which are conciliators of inflammation. Meloxicam has been shown, especially at its low therapeutic doses, selectively to hinder COX-2 over COX-1.
Meloxicam concentrations in synovial fluid range from 40% to 50% of those in plasma. The free portion in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin material in synovial fluid as compared with plasma. The significance of this penetration is unknown, but it might account for the fact that it carries out extremely well in treatment of arthritis in animal models.
What Takes Place if I Overdose Meloxicam
Look for emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms might include queasiness, vomiting, dizziness, sleepiness, black or bloody stools, spending blood, fever, urinating less than typical or not at all, shallow breathing, fainting, seizure (convulsions), or coma. We already wrote about Meloxicam abuse, so you can read more of the issue.
What Should I Avoid While Taking Meloxicam?
Do not drink alcohol (IYTmed.com strongly recommend to quit drinking alcohol). It might increase your risk of stomach bleeding.
Prevent taking meloxicam together with other NSAIDs such as aspirin, ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), or piroxicam (Feldene).
Ask a doctor or pharmacist before using other cold, allergy, or pain medication. Medicines much like meloxicam are included in numerous combination medicines. Taking specific items together can cause you to get excessive of a particular kind of drug Check the label to see if a medication contains an NSAID such as aspirin, ibuprofen, ketoprofen, or naproxen.
What Other Drugs Will Affect Meloxicam (Mobic)?
Ask your doctor prior to using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft). Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.
To about side effects of Meloxicam talk to your doctor about all other medications you use, especially:
- cyclosporine (Gengraf, Neoral, Sandimmune);
- lithium (Eskalith, Lithobid);
- a diuretic (water pill) such as furosemide (Lasix);
- glyburide (DiaBeta, Micronase);
- methotrexate (Rheumatrex, Trexall);
- a blood thinner such as warfarin (Coumadin, Jantoven);
- sodium polystyrene sulfonate (Kayexalate, Kionex);
- steroids (prednisone and others);
- an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others; or
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen (Orudis), naproxen (Aleve, Naprosyn), and others.
This list is not total and other drugs may connect with meloxicam. Inform your doctor about all medications you use. This consists of prescription, over the counter, vitamin, and organic products. Do not start a new medication without telling your doctor.